Faculty
Personal Profile
Quan Liu, M.D., Ph.D., is an associate professor in the School of Medicine at SUSTech as well as a junior attending surgeon. Dr. Liu achieved his Medical Degree from Harbin Medical University (HMU) in 2002. He received his surgical training at the Second Affiliated Hospital of HMU from late 2002 through 2008 and specialized in cardiothoracic surgery. Dr. Liu moved forward for his Ph.D. degree and spent over 8 years (from 2009 to 2017) at the University of Pittsburgh. He studied transplantation immunobiology, inflammation regulation, and immunobiology of IL-33 and regulatory T cells (Treg) in the Thomas E. Starzl Transplantation Institute at the University of Pittsburgh with Drs. Heth Turnquist and Adrian Morelli.
Research
1. Alloantigen presentation
2. Immunobiology of IL-33, Treg and ILC2 in settings of transplantation, inflammation regulation and tumor
3. Immunotherapy
Teaching
Undergraduate: Biochemistry, Physiology and Pathophysiology
Graduate: Immunology
Academic and Professional Appointments
2018.08-present, Associate Professor, School of Medicine, Southern University of Science and Technology
03.2014-04.2017, Research Associate， T.E. Starzl Transplantation Institute, University of Pittsburgh, USA
09.2014-08.2018, Deputy Chief Physician, Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, China
09.2008-08.2014, Attending Physician, Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, China
07.2005-08.2008, Resident, Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, China
Education
09.1997-06.2002, Clinical medicine, Undergraduate college, Haerbin Medical University
09.2002-06.2005, Surgery, Master, Haerbin Medical University
09.2008-12.2011, Surgery, Doctor, Haerbin Medical University
02.2009-08.2009, Clinical heart/lung transplantation observation, Presbyterian Hospital, University of Pittsburgh Medical Center, USA
12.2009-03.2012, Research fellow, T.E. Starzl Transplantation Institute, University of Pittsburgh, USA
03.2012-02.2014, Postdoctor, T.E. Starzl Transplantation Institute, University of Pittsburgh, USA
Publication
1. Li T, Zhang Z, Bartolacci JG, Dwyer GK , Liu Q, Mathews L, Velayutham M, Roessing A, Lee YC, Dai H, Shiva S, Oberbarnscheidt MH, Dziki JL, Mullett SJ, Wendell SG, Wilkinson JD, Webber SA, Wood-Trageser MA, Watkins SC, Demetris AJ, Hussey GS, Badylak SF, Turnquist HR. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. 2020;130:5397-5412.（Nature Index期刊，影響因子19.456）
2. Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A Geller. iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice. Mol Med. 2020;26:56.
3. Xiao F, Lin L, Chao Z, Shao C, Chen Z, Wei Z, Lu J, Huang Y, Li L, Liu Q, Liang Y, Tian L. Organic Spherical Nucleic Acids for the Transport of a NIR-II-Emitting Dye Across the Blood–Brain Barrier. Angew Chem Int Ed Engl. 2020; 59:9702-9710. (Nature Index期刊，影響因子16.823)
4. Lin L, Li Y, Liu M, Li Q, Liu Q#, Li R#. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging. 2020;12:1685-1703. （#共同通訊作者，影響因子5.955）
5. Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR. IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury. JCI Insight. 2019;4(6). pii: 123919. （影響因子9.484）
6. Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016;126:2805-20. （Nature Index 期刊，影響因子19.456，高被引論文）
7. Zhuang Q*, Liu Q*, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016;7:12623. （*共同第一作者，Nature Index 期刊，影響因子17.694）
8. Liu Q, Wang Y, Nakao A, Zhang W, Gorantla V, Zheng XX. Heart allograft tolerance induced and maintained by vascularized hind-limb transplant in rats. Clin Dev Immunol. 2013; 2013:483856.
9. Matta BM, Reichenbach DK, Zhang X, Mathews L, Koehn BH, Dwyer GK, Lott JM, Uhl FM, Pfeifer D, Feser CJ, Smith MJ, Liu Q, Zeiser R, Blazar BR, Turnquist HR. Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GVHD. Blood. 2016;128:427-39. (影響因子25.476)
10. Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH1, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015;125:3183-92. (影響因子25.476)
11. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39. (影響因子12.067)
12. Rosborough BR, Ra?ch-Regué D, Liu Q, Venkataramanan R, Turnquist HR, Thomson AW. Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant. 2014;14:2173-80. (影響因子9.369)
13. Matta BM, Lott JM, Mathews LR, Liu Q, Rosborough BR, Blazar BR, Turnquist HR. IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J Immunol. 2014;193:4010-20. (影響因子5.426)
14. Rosborough BR, Mathews LR, Matta BM, Liu Q, Ra?ch-Regué D, Thomson AW, Turnquist HR.Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. J Immunol. 2014;192:3470-3. (影響因子5.426)
15. Du Q, Zhang X, Liu Q, Zhang X, Bartels C, Geller DA. Nitric Oxide Production Upregulates Wnt/β-catenin Signaling By Inhibiting Dickkopf-1. Cancer Res. 2013; 73: 6526-37. （Nature Index 期刊, 影響因子13.312）
16. Cheng L, Guo H, Qiao X, Liu Q, Nie J, Li J, Wang J, Jiang K. T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading. Diagn Pathol. 2013;8:168.
17. Zhang D, Shen M, Mikita A, Zhang W, Liu Y, Liu Q, Dai Y, Zhang C, Zheng S, Zheng XX. Targeting uncoupling protein-2 improves islet graft function. Cell Transplant. 2011;20:421-9.
18. Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Stolz DB, Zheng XX, Demetris AJ, Liew FY, Wood KJ, Thomson AW. IL-33 expands suppressive CD11b+ Gr-1int and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol. 2011; 187: 4598-610. (影響因子5.426)
19. Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010; 116: 2694-705. (影響因子25.476)
20. 刁力為,劉大勇,葉明,劉泉,亓峰,孫振東,陳子道,姚志發,吳乃石.熱休克預適應對心臟移植供心保護作用的實驗研究[J].哈爾濱醫科大學學報,2010,44(05):443-446.
21. 吳乃石,刁力為,劉泉,趙林,亓鋒,劉大勇.托拉塞米在重癥心臟聯合瓣膜置換病人圍手術期中的應用[J].中國新藥與臨床雜志,2006(10):753-755.
22. 劉泉,吳乃石,孫露,趙林林,刁力為,陳子道,杜金榮.嬰兒多發性心臟橫紋肌瘤一例[J].中華外科雜志,2006(06):368.
23. 劉泉,臧旺福,田海.一種新的大鼠同種主動脈瓣異位移植模型[J].中華實驗外科雜志,2005(10):114-115.
Literature review
24. Liu Q, Turnquist HR. Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant. 2016;21:45-52.
25. Liu Q, Turnquist HR. Implications for Interleukin-33 in solid organ transplantation. Cytokine. 2013;62:183-94.
26. 劉泉,楊木清,代賀龍.匹茲堡大學Starzl移植研究所學習期間的見聞與思考[J].實用器官移植電子雜志,2018,6(06):477-478.
27. 劉泉,齊忠權.移植免疫與器官再生的研究進展[J].實用器官移植電子雜志,2018,6(02):90-92.