師資
主要學(xué)術(shù)成績簡介
張健，南方科技大學(xué)倫敦國王學(xué)院醫(yī)學(xué)院副院長，南科大醫(yī)學(xué)院教授，博士生導(dǎo)師，致誠書院院長，“百千萬人才工程”國家級人選，國務(wù)院特貼專家，深圳市引進國家級領(lǐng)軍人才（A類）。2011年創(chuàng)建華南地區(qū)首家轉(zhuǎn)化醫(yī)學(xué)研究中心并任主任。曾創(chuàng)建和擔(dān)任“長壽與老年相關(guān)疾病”教育部重點實驗室主任。目前擔(dān)任廣東省細胞微環(huán)境與疾病研究重點實驗室學(xué)術(shù)委員會委員；中國抗癌協(xié)會腫瘤轉(zhuǎn)移專業(yè)委員會常委和青委會主任委員；中國生物技術(shù)學(xué)會轉(zhuǎn)化醫(yī)學(xué)分會副主任委員；廣東省轉(zhuǎn)化醫(yī)學(xué)學(xué)會顧問委員會主任；深圳市生物醫(yī)藥促進會副會長；中國腫瘤防治聯(lián)盟深圳市聯(lián)盟副主席；2015-2017《Medical Oncology》副主編。SCI 發(fā)表文章總數(shù)130余篇。 博士畢業(yè)于美國密歇根大學(xué)醫(yī)學(xué)院，2004 年起任美國國防部（DOD）醫(yī)學(xué)課題評審委員，從2009 年起任我國教育部長江學(xué)者和自然科學(xué)基金杰青、國合、重點、海外優(yōu)青、面上等項目評審專家。2013 年被選為“全國優(yōu)秀科技工作者”，2014 年入選“國家百千萬人才工程”和“國家有突出貢獻中青年專家”。2016年獲批深圳市引進國家級領(lǐng)軍人才（A類），負責(zé)籌備和成功申報并獲批南方科技大學(xué)醫(yī)學(xué)院臨床醫(yī)學(xué)和生物醫(yī)學(xué)科學(xué)本科專業(yè)。
研究領(lǐng)域
腫瘤轉(zhuǎn)化醫(yī)學(xué)研究
腫瘤耐藥、復(fù)發(fā)與轉(zhuǎn)移
衰老與腫瘤
教育經(jīng)歷
1981-1986: 學(xué)士，天津醫(yī)科大學(xué)臨床醫(yī)學(xué)系
1997-1998: 碩士，Old Dominion University & East Virginia Medical School 免疫學(xué)專業(yè)
1998-2001: 博士， University of Michigan 病理學(xué)專業(yè)
主要工作經(jīng)歷
1986.8-1995.1 天津市第三醫(yī)院/天津市老年醫(yī)學(xué)研究所，內(nèi)科住院醫(yī)師、主治醫(yī)師
1995.1-1996.8 美國威斯康星-麥迪遜大學(xué)老年醫(yī)學(xué)研究所 世界衛(wèi)生組織獎學(xué)金訪問學(xué)者
1996.8-1998.8 東弗吉尼亞醫(yī)學(xué)院老年醫(yī)學(xué)研究中心Visiting Research Scientist
1998.8-2004.6 美國密歇根大學(xué)醫(yī)學(xué)院博士在學(xué)/研究員
2004.7-2010.12 美國匹茲堡大學(xué)和密歇根大學(xué)醫(yī)學(xué)院助理教授 (Tenure track)
2011.1-2016. 7 長壽與老年相關(guān)疾病省部共建教育部重點實驗室/廣西醫(yī)科大學(xué)轉(zhuǎn)化醫(yī)學(xué)院就中心主任/教授
2016.3- 美國匹茲堡大學(xué)醫(yī)學(xué)院兼職教授
2016.7- 南方科技大學(xué)醫(yī)學(xué)院教授
榮譽
2019-深圳市生物醫(yī)藥促進會副會長
2018-中國腫瘤防治聯(lián)盟深圳市聯(lián)盟副主席
2014-獲得國務(wù)院政府特殊津貼專家
2013-入選國家百千萬人才工程國家級人選并獲“有突出貢獻的中青年專家”榮譽稱號
2013-美國基礎(chǔ)泌尿研究學(xué)會(SBUR)頒發(fā)的International lecturer證書
2012-全國優(yōu)秀科技工作者
2011-廣西壯族自治區(qū)八桂學(xué)者、廣西壯族自治區(qū)政府參事
2007-Mentoring Dr. Yi Lu, Young Investigator Travel Award, ASBMR
2005-Mentoring Dr. Yi Lu, Scholar-in-Training Award, AACR
2003-Scholar-in-Training Award, AACR
2003- Plenary Poster Award of 25th Annual Meeting of American Society for Bone and Mineral Research
2002-Alice L. Jee Memorial Young Investigator Award
2000-Plenary Poster Award of 22nd Annual Meeting of American Society for Bone and Mineral Research
1994- Fellowship Award, World Health Organization (WHO)
近六年發(fā)表的SCI論文
1. Wang W, Yang X, Dai J, Lu Y, Zhang J, and Keller E*. Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion. Oncogene, 2019, 38(23):4540-45559
2. Su W, Wang L, Niu F, Zou L, Guo C, Wang Z, Yang X, Wu J, Lu Y, Zhang J, Beer DG, Yang Z, Chen G. LINC00857 knockdown inhibits cell proliferation and induces apoptosis via involving STAT3 and MET oncogenic proteins in esophageal adenocarcinoma. Aging-US. 2019, 11(9):2812-2821
3. Guo H, Wang F, Diao Y, Zhang Z, Chen Q, Qian CN, Keller ET, Zhang J*, Lu Y*. Knockdown of Notch1 inhibits nasopharyngeal carcinoma cell growth and metastasis via downregulation of CCL2, CXCL16, and uPA. Molecular Carcinogenesis, 2019, 58:1886-1896
4. Yun C, Chang M, Hou G, Lan T, Yuan H, Su Z, Zhu D, Liang W, Li Q, Zhu H, Zhang J, Lu Y*, Deng J*, Guo H*. Mangiferin suppresses allergic asthma symptoms by decreased Th9 and Th17 responses and increased Treg response. Molecular Immunology. 2019, 114:233-242
5. Song Q, Qin S, Pascal L, Zou C, Wang W, Tong H, Zhang J, Catalona W, Dhir R, Morrell M, Balasubramani G, Lu Y*, Wang Z*. SIRPB1 promotes prostate cancer cell proliferation via Akt activation. The Prostate, March 2020, 80 (4): 352-364
6. Wei T, Wang H, Wu X, Lu Y, Guan S, Dong F, Dong C, Zhu G, Bao Y, Zhang J*, Wang G*, and Li H*. In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy. Chin J Integr Med. 2020, 26(9):663-669
7. Qin S, Jiang J, Tang B, Lu Y, Nice EC, Huang C*, Zhang J*, He W*. Emerging Role of Tumor Cell Plasticity in Modifying Therapeutic Response. Signal Transduction and Targeted Therapy, 2020, 5(1):228
8. Yu W, Zhang X, Zhang W, Xiong M, Lin Y, Chang M, Xu L, Lu Y*, Liu Y*, Zhang J*. 19-Hydroxybufalin inhibits non-small cell lung cancer cell proliferation and promotes cell apoptosis via the Wnt/β-catenin pathway. Exp Hematol Oncol. 2021, 10(1):48
9. Lu Y, Di YP*, Chang M, Huang X, Chen Q, Hong N, Kahkonen BA, Di ME, Yu C, Keller ET, Zhang J*. Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation. J Transl Med. 2021, 19(1):163
10. Chang M, Zhu D, Chen Y, Zhang W, Liu X, Li XL, Cheng Z, Su Z, Zhang J*, Lu Y*, Guo H*. Total flavonoids of Litchi Seed attenuate prostate cancer progression via inhibiting AKT/mtor and NF-kb signaling pathways. Front Pharmacol. 2021,12:758219
11. Wei T, Lin R, Fu X, Lu Y, Zhang W, Li Z, Zhang J*, and Wang H*. Epigenetic regulation of the DNMT/MT1G/KLF4/CA9 axis synergizes the anticancer effects of sorafenib in hepatocellular carcinoma. Pharmacological Research. 2022, 180:106244.
12. Chen E, Yi J, Jiang J, Zou Z, Mo Y, Ren Q, Lin Z, Lu Y, Zhang J* and Liu J*. Identification and validation of a fatty acid metabolism-related lncRNA signature as a predictor for prognosis and immunotherapy in patients with liver cancer. BMC Cancer. 2022, 22:1037
13. Zhang Z, Qin S, Chen Y, Zhou L, Yang M, Tang Y, Zuo J, Zhang J, Mizokami A, Nice E, Chen H, Huang C, Wei X. Inhibition of NPC1L1 disrupts adaptive responses of drug-tolerant persister cells to chemotherapy. EMBO Molecular Medicine, 2022, 14(2):e14903.
14. Zhang X, Wei T, Wu C, Jiang J, Chen S, Hu Y, Lu Y, Sun D, Zhai L, Zhang J*, Liu C. Cryo-EM structure reveals polymorphic ligand-bound states of IGF1R. Journal of Molecular Biology. 2022, 2022 May 15;434(9):167536. doi: 10.1016/j.jmb.2022.167536. Epub 2022 Mar 15
15. Zhang X, Wu C, Wei T, Lu Y*, Liu C*, Zhang J*. Cryo-EM studies of the apo states of human IGF1R. BBRC. 2022, 618: 148-152.
16. Chang M, He Y, Liu C, Lin R, Huang X, Liang D, Zhang J*, Lu Y*. Downregulation of SEPTIN5 inhibits prostate cancer progression by increasing CD8+T cell infiltration. International Journal of Biological Science. 2022, 18 (16):6035-51.
17. Chen E, He Y, Jiang J, Yi J, Zou Z, Song Q, Ren Q, Lin Z, Lu Y*, Liu J*, and Zhang J*. CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK/ERK pathway. Experimental Hematology & Oncology. 2023, 12:9.
18. Qin S, Zhang Z, Huang Z, Luo Y, Weng N, Li B, Tang Y, Zhou L, Jiang J, Lu Y, Shao J, Xie N, Nice EC, Chen Z, Zhang J*, Huang C*. CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1 mediated micropinocytosis. Drug Resistance Updates. 2023, 66:100906.
19. Ye X, Liu J, Quan R, Lu Y*, Zhang J*. DKK1 affects survival of patients with head and neck squamous cell carcinoma by inducing resistance to radiotherapy and immunotherapy. Radiotherapy and Oncology. 2023, 181:109485.
20. Qiao T, Yang W, He X, Song P, Chen X, Liu R, Xiao J, Yang X, Li M, Gao Y, Chen G, Lu Y, Zhang J*, Leng J*, and Ren H*. Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis. Cell Death & Diseases. 2023, 14:117.
21. Ye X, Huang X, Fu X, Zhang X, Lin R, Zhang W, Zhang J*, Lu Y *. Myeloid-like Tumor Hybrid Cells in Bone Marrow Promote Promote Progression of Prostate Cancer Bone Metastasis. Journal of Hematology & Oncology. 2023, 16:46.
22. Chen X, Hao Y, Liu Y, Zhong S, You Y, Ao K, Chong T, Luo X, Yin M, Ye M, He H, Lu A, Chen J, Li X*, Zhang J*, and Guo X*. NAT10/ac4C/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer. Advanced Science, 2023, 2302705.
23. Wu J, Huang X, Li X, Zhou H, Chen X, Chen Y, Guo Y, Huang J, Huang H, Huang Z, Chen G, Yang Z*, Zhang J*, and Su W*. Suppression of the long non coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A. Discover Oncology, 2024, 15:3.
24. Wang F, Fu X, Chang M, Wei T, Lin R, Tong H, Zhang X, Yuan R, Zhou Z, Huang X， Zhang W, Su W, Lu Y*, Liang Z*, and Zhang J*. The interaction of calcium-sensing receptor with KIF11 enhances cisplatin resistance in lung adenocarcinoma via BRCA1/cyclin B1 pathway. International Journal of Biological Science. 2024, 20 (10):3892-3910.
25. Wei T, Lin R, Lu Y, Jin DY*, Zhang J*, Sham MH*. Protein phosphatase EYA1 regulates the dephosphorylating and turnover of BCL2L12 to promote glioma development. International Journal of Biological Science. 2025, In press.
目前在修稿或評審中的文章
1. Zhang Y, Xu Z, Ye X, Lian J, Ye B, Li H, Zheng D, Jiang Y, Zhao C, Liu Y, Lin Z, Zang D, Wang E, Cai M, Xie Z, Zhou P, Guan X, Hong X, Lu Y, Zhang Y*, Zhang J*, Zheng H*, Kong FM*, Yu H*. Revealing the cold TIME with a novel tumor-macrophage fusion cell subtype in HPV-cervical cancer by integrating scRNA-seq and spatial transcriptomics. Science Immunology. 2025, under review.
2. Zhang X, Yu W, Sun Y, Ye X, He Y, Huang X, Wang F, Lu Y*, Zhang J*. Anti-inflammatory resveratrol protects mice from early mortality after hematopoietic stem cell transplantation. Journal of Cellular and Molecular Medicine. 2024 in Revision
3. Ye B, Wang Z, Bai Y, Zhang X, Zhang R, Lian J, Liu X, Zhang Y, Xu Z, Yang L, Jin H, Chen F, Xie Z, Zhou P, Tan J, Zeng S, Du C, Yang M, Li H, Duan J, Li Z, Yang H, Cai Y, Wu H, Liu CC, Cai J, Lu Y, Zhang J, Wu H, Hong X*, Zheng H*, Liu L*, Yu H*. In Situ Detection of Circulating Tumor Cells. Nature Cancer, 2024 submitted
4. Zhang W, Qin S, Li X, Lu S, Chang M, Wei T, Huang X, Tong H, Lu X*, Guo X*, Lu Y*, Zhang J*. SMC4 promotes prostate cancer cell proliferation and metastasis via Rheb/mTOR pathway. Advanced Science, 2024 in Revision