師資
個人簡介：
蘇楊博士，南方科技大學生命科學學院研究助理教授，碩士研究生導師。江蘇海洋大學學士，南京師范大學微生物學博士，上海交通大學和南方科技大學博士后。主要研究磷酸肌醇的功能和蛋白質穩(wěn)態(tài)的代謝調控。先后獲國家自然科學基金面上項目、國家自然科學基金青年項目、廣東省自然科學基金面上項目、深圳市基礎研究面上項目資助。以第一作者或共第一作者在Nature Chemical Biology, Molecular Cell，mBio，F(xiàn)EBS Journal等雜志上發(fā)表研究論文多篇。入選深圳市高層次人才計劃。
研究領域：
Culling-ING ligase(CRL)泛素連接酶是最大的E3泛素連接酶群體，介導體內總泛素化的20%。CRLs需要被擬素化修飾激活才能行使功能，受去擬素酶CSN復合體抑制。我們研究CRL擬素化的代謝分子調控路徑，包括多磷酸肌醇小分子和營養(yǎng)。
工作經(jīng)歷：
2021年11月~至今，南方科技大學，神經(jīng)生物學系，研究助理教授
2018年12月~2021年7月，南方科技大學，神經(jīng)生物學系，博士后，合作導師：饒楓 教授
2016年07月~2018年09月，上海交通大學醫(yī)學院，微生物與免疫學學系，博士后，合作導師：姚玉峰 教授
學習經(jīng)歷：
2011年09月~2016年06月，南京師范大學，生命科學學院，博士，導師：黃鷹 教授
2007年09月~2011年06月，江蘇海洋大學，海洋學院，學士
代表文章：
(1) Hongyun Zhang(#), Bobo Zhang(#), Yuebo Zhao(#), Yang Su(#), Yifan Peng, Xiaoli Yang, Hongming Zhao, Hongyu Liu, Jie Feng, Hongjing Pei, Wenyong Zhang, Niu Huang, Kai Jiang, Masatoshi Ito, Guizhen Liu, Nicolas Jork, Karen E. Anderson, Li Zhao, Eiichiro Nagata8, Henning J. Jessen, Philip T. Hawkins, Changzheng Du, Feng Rao?*. Oncometabolite 5-IP7 inhibits inositol 5-phosphatases to license E-cadherin endocytosis. Nature Chemical Biology. 2025 10.1038/s41589-025-02005-z.
(2) Yang Su(#), Yifan Luo(#), Peitao Zhang, Hong Lin, Weijie Pu, Hongyun Zhang, Huifang Wang, Yi Hao, Yihang Xiao, Xiaozhe Zhang, Xiayun Wei, Siyue Nie, Keren Zhang, Qiuyu Fu, Hao Chen, Niu Huang, Yan Ren, Mingxuan Wu, Billy Kwok Chong Chow, Xing Chen, Wenfei Jin, Fengchao Wang*, Li Zhao*, Feng Rao*, Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis, Molecular Cell, 2023 Jun 6;83(13):2316-2331.
(3) Yang Su(#), Jianhui Li(#), Wenting Zhang(#) Jinjing Ni, Rui Huang, Zuoqiang Wang, Sen Cheng, Yue Wang, Zhixin Tian, Qiuxiang Zhou, Donghai Lin, Wenjuan Wu, Christoph M. Tang, Xiaoyun Liu*, Jie Lu*, Yu-Feng Yao*, Methylation of PhoP by CheR regulates Salmonella virulence, mBio. 2021 Sep 21; e0209921. doi: 10.1128/mBio.02099-21.
(4) Su Y, Yang Y, Huang Y(*), Loss of ppr3, ppr4, ppr6 or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe, FEBS J, 2017, 284(2): 324-337.
(5) Su Y(#), Chen C(#), Huang L(#), Yan J, Huang Y(*), Schizosaccharomyces pombe Homologs of Human DJ-1 Are Stationary Phase Associated Proteins That Are Involved in Autophagy and Oxidative Stress Resistance, PloS One, 2015, 10(12): e0143888.
(6) Zhao Q(#), Su Y(#), Wang Z(#), Chen C, Wu T, Huang Y(*), Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe, Bmc Evol Biol, 2014, 14: 86.
(7) Su Y, Chen J, Huang Y(*), Disruption of ppr3, ppr4, ppr6, or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe, FEMS Microbiol Lett, 2018 Aug 1;365(16).
(8) Ren J(#), Sang Y(#), Qin R, Su Y, Cui Z, Mang Z, Li H, Lu S, Zhang J, Cheng S, Liu X, Li J, Lu J, Wu W, Zhao GP, Shao F, Yao YF(*), Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation, Emerg Microbes Infect, 2019;8(1):55-69.
(9) Rao F(*), Lin H, Su Y, Cullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and NewPhysiologic Players, Adv Exp Med Biol, 2020;1217:47-60.
(10) Lin H(#), Zhang X(#), Liu L(#), Fu Q, Zang C, Ding Y, Su Y, Xu Z, He S, Yang X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T*, Rao F*, Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome, Proceedings of the National Academy of Sciences, 2020 Feb 25;117(8):4117-4124.
(11) Xiaozhe Zhang, Shaodong Shi, Yang Su, Xiaoli Yang, Sining He, Jing Wu, Jian Zhang, Feng Rao*, Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat, J Biol Chem, 2020 Jun 3;jbc.RA120.014375.
(12) Jianhui Li(#), Shuting Liu(#), Yang Su, Jie Ren, Yu Sang, Jinjing Ni, Jie Lu, Yu-Feng Yao*, Acetylation of PhoP K88 is involved in regulating Salmonella virulence, Infect Immun, 2020 Dec 14;IAI.00588-20.
(13) Hong Lin(#), Yuan Yan(#), Yifan Luo(#), Wing Yan So(#), Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang & Feng Rao*, IP6 -assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion against hyperinsulinemia, Nature Communications, 2021 Apr 28;12(1):2461.
(14) Yifan Luo, Yang Su & Feng Rao*, Role of NEDD8 and neddylation dynamics in DNA damage response, Genome Instability & Disease, 2021, volume 2, pages139–149.
(15) Zhenlei Zhang(#), Yufan Wu(#), Jinrong Fu(#), Xiujie Yu, Yang Su, Shikai Jia, Huili Cheng, Yan Shen, Xianghui He, Kai Ren, Xiangqian Zheng, Haixia Guan*, Feng Rao*, Li Zhao*. Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis. Nature Communications 2024 May 15;15(1):4108.