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個(gè)人簡(jiǎn)介：田瑞琳，南方科技大學(xué)醫(yī)學(xué)院助理教授、副研究員、博士生導(dǎo)師。2015年畢業(yè)于北京大學(xué)生物科學(xué)專業(yè)，2015年9月至2020年12月在美國(guó)加州大學(xué)舊金山分校（UCSF）取得博士學(xué)位，并進(jìn)行博士后訓(xùn)練，2020年底加入南方科技大學(xué)醫(yī)學(xué)院。

本課題組結(jié)合CRISPR基因表達(dá)調(diào)控系統(tǒng)（CRISPRi和CRISPRa）與人類誘導(dǎo)多能干細(xì)胞（iPSC）分化技術(shù)，開(kāi)發(fā)出在人類神經(jīng)元和神經(jīng)膠質(zhì)細(xì)胞中進(jìn)行大規(guī)模遺傳篩選的平臺(tái)。本課題利用這一平臺(tái)，并結(jié)合各種細(xì)胞分子生物學(xué)技術(shù)和單細(xì)胞測(cè)序等多組學(xué)方法，研究人類神經(jīng)系統(tǒng)疾病的分子細(xì)胞生物學(xué)機(jī)制。

實(shí)驗(yàn)室網(wǎng)站：https://tianlab.top/

教育背景：2011.9-2015.6 本科 北京大學(xué) 生物科學(xué)

2015.9-2020.6 博士 加州大學(xué)舊金山分校 生物物理

工作經(jīng)歷：2020.6-2020.12 博士后 加州大學(xué)舊金山分校

獲獎(jiǎng)情況及榮譽(yù)：

2016年 Tau consortium fellowship by the Tau consortium

2015年 北京市優(yōu)秀畢業(yè)生

2015年 北京大學(xué)優(yōu)秀畢業(yè)生

2014年 國(guó)家獎(jiǎng)學(xué)金

2013年 北京大學(xué)五四獎(jiǎng)學(xué)金

研究領(lǐng)域：

1. 神經(jīng)發(fā)育疾病和神經(jīng)退行性疾病的分子細(xì)胞生物學(xué)機(jī)制

2. 神經(jīng)膠質(zhì)細(xì)胞與神經(jīng)元相互作用

3. 基于CRISPR和誘導(dǎo)多能干細(xì)胞（iPSC）的遺傳篩選方法的開(kāi)發(fā)

4. 單細(xì)胞組學(xué)/系統(tǒng)生物學(xué)

發(fā)表論文：

1. Samelson, A., Tran, Q.D., Robinot, R., ... , Tian, R.*, Kampmann, M.* (2022). BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. Nature Cell Biology, 10.1038/s41556-021-00821-8 (* corresponding authors)

2. Tian, R.*, Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Nalls, M. A., ... & Kampmann, M.* (2021). Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. Nature Neuroscience, 10.1038/s41593-021-00862-0 (* corresponding authors)

3. Semesta, K. M.,Tian, R., Kampmann, M., von Zastrow, M., & Tsvetanova, N. G. (2020). A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. PLoS genetics, 16(10), e1009103.

4. Ramkumar, P., Abarientos, A. B., Tian, R., Seyler, M., Leong, J. T., Chen, M., ... & Kampmann, M. (2020). CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood advances, 4(13), 2899-2911.

5. Guo, X., Aviles, G., Liu, Y., Tian, R., Unger, B.A., Lin, Y.H.T., Wiita, A.P., Xu, K., Correia, M.A. and Kampmann, M., (2020). Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway. Nature, 579(7799), pp.427-432.

6. Tian, R., Gachechiladze, M.A., Ludwig, C.H., Laurie, M.T., Hong, J.Y., …, Ward, M.E. & Kampmann, M., (2019). CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons. Neuron, 10.1016/j.neuron.2019.07.014

7. Ramkumar, P., Tian, R., Seyler, M., Leong, J. T., Chen, M., Choudhry, P., ... & Kampmann, M., (2019). CRISPR-based screens uncover determinants of immunotherapy response and potential combination therapy strategies. bioRxiv, 833707.

8. Torres, S.E., Gallagher, C.M., Plate, L., Gupta, M., Liem, C.R., Guo, X., Tian, R., Stroud, R.M., Kampmann, M., Weissman, J.S. and Walter, P., (2019). Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. eLife, 8.

9. Chen, J.J., Nathaniel, D.L., Raghavan, P., Nelson, M., Tian, R., …, and Kampmann, M., (2019). Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. Journal of Biological Chemistry, pp.jbc-RA119.

10. Zhang, Y. J., Guo, L., ... Tian,R., … & Petrucelli, L. (2019). Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly (PR) toxicity. Science, 363(6428), eaav2606.

11. Boettcher, M., Tian, R., Blau, J. A., Markegard, E., Wagner, R. T., Wu, D., ... & McManus, M.T., (2018). Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nature biotechnology, 36(2), 170.

12. Mavor, D., Barlow, K. A., …, Tian, R., … , Kampmann, M. & Fraser, S. J., (2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Biology open, 7(7), bio036103.

13. Pal, S., Lant, B., Yu, B., Tian, R., Tong, J., Krieger, J. R., ... & Derry, W. B. (2017). CCM-3 promotes C. elegans germline development by regulating vesicle trafficking cytokinesis and polarity. Current Biology, 27(6), 868-876.

14. Xie, Z., Jay, K.A., Smith, D.L., Zhang, Y., Liu, Z., Zheng, J., Tian, R., Li, H. and Blackburn, E.H. (2015). Early telomerase inactivation accelerates aging independently of telomere length. Cell, 160(5), pp.928-939.

15. He, C., Tsuchiyama, S.K., Nguyen, Q.T., …, Tian, R., …, Kennedy, K.B. & Polymenis, M., (2014). Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS genetics, 10(12), p.e1004860.