個人簡介：
朱瓊花，南方科技大學研究助理教授。2016年博士畢業于德國洪堡大學，同年進入德國亥姆霍茲聯合會馬克斯-德爾布呂克分子醫學中心從事博士后研究，2019年加入南方科技大學并工作至今。現主要基于多種組學技術、高通量篩選技術研究腫瘤演化、腫瘤異質性及基因轉錄調控。
研究領域：
1. 腫瘤演化和腫瘤異質性；
2. 基因轉錄調控；
3. 單細胞組學；
工作經歷：
2019 - 至今 南方科技大學
2016 - 2019 德國亥姆霍茲聯合會馬克斯-德爾布呂克分子醫學中心
代表文章：
1. Zhu Q#*, Zhao X#, Zhang Y#, Li Y#, Liu S#, Han J, Sun Z, Wang C, Deng D, Wang S, Tang Y, Huang Y, Jiang S, Tian C, Chen X, Yuan Y, Li Z, Yang T, Lai T, Liu Y, Yang W, Zou X, Zhang M, Cui H, Liu C, Jin X, Hu Y, Chen A, Xu X, Li G, Hou Y, Liu L*, Liu S*, Fang L*, Chen W*, Wu L*. Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines. Nat Commun. 2023 Dec 9;14(1):8170. doi: 10.1038/s41467-023-43991-9. PMID: 38071219; PMCID: PMC10710513.
2. Yi H, He Y, Zhu Q, Fang L. RUNX Proteins as Epigenetic Modulators in Cancer. Cells. 2022 Nov 20;11(22):3687.
3. Cui H, Yi H, Bao H, Tan Y, Tian C, Shi X, Gan D, Zhang B, Liang W, Chen R, Zhu Q, Fang L, Gao X, Huang H, Tian R, Sperling SR, Hu Y, Chen W. The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling. Nat Commun. 2022 Aug 9;13(1):4680.
4. Zhao T, Sun Y, Zhu Q, Li X, Baghaee M, Wang Y, Yuan H*. A contraction-reaction-diffusion model for circular pattern formation in embryogenesis. Journal of the Mechanics and Physics of Solids. 2021. 157.
5. Fang L#*, Li G#, Sun Z, Zhu Q, Cui H, Li Y, Zhang J, Liang W, Wei W, Hu Y, Chen W*. CASB: A concanavalin A-based sample barcoding strategy for single-cell sequencing. Mol Syst Biol, 2021 Apr;17(4):e10060.
6. Yi H#, Li G#, Long Y, Liang W, Cui H, Zhang B, Tan Y, Li Y, Shen L, Deng D, Tang Y, Mao, C, Tian S, Cai Y, Zhu Q, Hu Y*, Chen W*, Fang L*. Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT. Oncogene, 2020. 39(28): p. 5152-5164.
7. Fang L#*, Wang W#, Li G#, Zhang L, Li J, Gan D, Yang J, Tang Y, Ding Z, Zhang M, Zhang W, Deng D, Song Z, Zhu Q, Cui H, Hu Y, Chen W*. CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators. Mol Syst Biol. 2020 Nov;16(11):e10025.
8. Praktiknjo S#,*, Obermayer B#, Zhu Q#, Fang L, Liu H, Quinn H, Stoeckius M, Kocks C, Birchmeier W*, Rajewsky N*. Tracing tumorigenesis in a solid tumor model at single-cell resolution. Nat Commun. 2020 Feb 20;11(1):991.
9. Zhu Q#, Fang L#, Heuberger J, Kranz A, Schipper J, Scheckenbach K, Vidal RO, Sunaga-Franze DY, Müller M, Wulf-Goldenberg A, Sauer S, Birchmeier W. The Wnt-driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell reports. 2019 Jan 26: 415–428.
10. Ma Y#, Peng Y#, Zhu Q#, Gao A#, Chao B, He Q, Li J, Hu Y, Zhou Y. CHOP activator LGH00168 induces necroptosis via reactive oxygen species-induced ER stress and NF-κB inhibition in A549 lung cancer cells. Acta Pharmacologica Sinica. 2016 Sep;37(10):1381-1390.
11. Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Weis WI, von Kries JP, Birchmeier W. A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis. Cancer Research. 2016 Feb 15;76(4):891-901.
12. Wend P, Fang L, Zhu Q, Schipper JH, Loddenkemper C, Kosel F, Brinkmann V, Eckert K, Hindersin S, Holland JD, Lehr S, Kahn M, Ziebold U, Birchmeier W. Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J. 2013 Jul 17;32(14):1977-89.
