師資
何川博士,南方科技大學化學系研究員/副教授,博士生導師;國家特聘青年專家、國家優秀青年基金獲得者、廣東省珠江青年拔尖人才、深圳市海外高層次人才、深圳市優秀科技創新人才“杰青項目”獲得者。
2004-2008年,武漢大學,理學學士。
2008-2013年,武漢大學,理學博士,導師:雷愛文。
2013-2017年,劍橋大學,博士后/瑪麗居里研究員,合作導師:Matthew Gaunt。
2018年-至今,南方科技大學,副教授/研究員,課題組長。
獨立工作以來,立足手性化學學科前沿,圍繞主族元素雜原子手性化學開展了系統原創性的研究,在極具挑戰的手性有機硅化學和硼化學領域做出了重要的科學突破。針對雜原子中心手性創建存在的關鍵科學問題,發展了多種構筑硅中心手性和硼中心手性化合物的核心技術,高效構建了一系列全新的硅、硼、鍺中心手性化合物,有效豐富和拓展了主族元素雜原子手性化學的空間,推動了其在手性功能材料等領域的應用,取得了特色鮮明的創新性研究成果。特別是圍繞手性有機硅化學,系統打造發展了一類具有標簽特色的不對稱催化脫氫偶聯反應(Si-CADC, Catalytic Asymmetric Dehydrogenative Coupling toward Si-stereogenic silanes),建立了構筑硅中心手性的有效方法和核心技術。
在南科大已發表獨立通訊作者論文50余篇,包括Nat. Chem. 1篇, Nat. Synth. 1篇, Acc. Chem. Res. 1篇, CCS Chem. 1篇, J. Am. Chem. Soc. 4篇,Angew. Chem. Int. Ed. 7篇,Nat. Commun. 2篇,Chem. Soc. Rev. 1篇,Chem 1篇,ACS Catal. 4篇,Chem. Sci. 2篇等;撰寫學術專著章節2篇。申請國家發明專利12項,已授權8項。2021年,獲Thieme Chemistry Journals Award。2022年,獲南科大“年度青年教授獎”和“校長青年科研獎”。2023年,入選Org. Chem. Front.新銳科學家。
代表論文(南科大通訊作者):
(1) Ren, L-Q.; Zhan, B.; Zhao, J.; Guo, Y.; Zu, B.; Li, Y.; He, C.* Modular Enantioselective Assembly of Multi-Substituted Boron-Stereogenic BODIPYs, Nat. Chem. 2025, 17, 83?91.
(2) Ge, Y.; Ke, J.; He, C.* Catalytic Asymmetric Dehydrogenative Si?H/X?H Coupling toward Si-Stereogenic Silanes, Acc. Chem. Res. 2025, 58, 375?398.
(3) Zhan, B.; Ren, L-Q.; Zhao, J.; Zhang, H.;* He, C.* Catalytic Asymmetric C–N Cross-Coupling towards Boron-Stereogenic 3-Amino-BODIPYs, Nat. Commun. 2025, 16, 438.
(4) Lin, W.; Ren, L-Q.; Chen, C. D.; Han, X.; Zhang, L.; Chen, Z.; Guo, J.;* He, C.* Cu-Catalyzed Asymmetric Hydrogermylation towards C- and Ge-Stereogenic Germanes, CCS Chem. 2025, 7, 1157?1167.
(5) Wu, L.; Zhang, L.; Guo, J.; Gao, J.; Ding, Y.; Ke, J.;* He, C.* Catalytic Asymmetric Construction of C- and Si-Stereogenic Silacyclopentanes via Hydrosilylation of Arylmethylenecyclopropanes, Angew. Chem., Int. Ed. 2024, 63, e202413753.
(6) Gao, J.; Ge, Y.;* He, C.* X-Type Silyl Ligands for Transition-Metal Catalysis, Chem. Soc. Rev. 2024, 53, 4648?4673.
(7) Yang, B.; Gao, J.; Tan, X.; Ge, Y.;* He, C.* Chiral PSiSi-Ligand Enabled Iridium-Catalyzed Atroposelective Intermolecular C?H Silylation, Angew. Chem., Int. Ed. 2023, 62, e202307812.
(8) Liu, M.-M.; Xu, Y.; He, C.* Catalytic Asymmetric Dehydrogenative Si?H/N?H Coupling: Synthesis of Silicon-Stereogenic Silazanes, J. Am. Chem. Soc. 2023, 145, 11727?11734.
(9) Zu, B.; Guo, Y.; Ren, L-Q.; Li, Y.;* He, C.* Catalytic Enantioselective Synthesis of Boron-Stereogenic BODIPYs, Nat. Synth. 2023, 2, 564?571.
(10) Yuan, W.; Zhu, X.; Xu, Y.; He, C.* Synthesis of Si-Stereogenic Silanols by Catalytic Asymmetric Hydrolytic Oxidation, Angew. Chem., Int. Ed. 2022, 61, e202204912.
(11) Chen, S.; Zhu, J.; Ke, J.; Li, Y.; He, C.* Enantioselective Intermolecular C?H Silylation of Heteroarenes for the Synthesis of Acyclic Si-Stereogenic Silanes, Angew. Chem., Int. Ed. 2022, 61, e202117820.
(12) Zu, B.; Guo, Y.; He, C.* Catalytic Enantioselective Construction of Chiroptical Boron-Stereogenic Compounds, J. Am. Chem. Soc. 2021, 143, 16302?16310.
(13) Guo, Y.; Liu, M.-M.; Zhu, X.; Zhu, L.; He, C.* Catalytic Asymmetric Synthesis of Silicon-Stereogenic Dihydrodibenzosilines: Silicon-Central to Axial Chirality Relay, Angew. Chem., Int. Ed. 2021, 60, 13887?13891.
(14) Zhu, J.; Chen, S.; He, C.* Catalytic Enantioselective Dehydrogenative Si?O Coupling to Access Chiroptical Silicon-Stereogenic Siloxanes and Alkoxysilanes, J. Am. Chem. Soc. 2021, 143, 5301?5307.
(15) Ke, J.; Liu, W.; Zhu, X.; Tan, X.; He, C.* Electrochemical Radical Silyl-Oxygenation of Activated Alkenes, Angew. Chem., Int. Ed. 2021, 60, 8744?8749.
(16) Chen, S.; Mu, D.; Mai, P-L.; Ke, J.; Li, Y.; He, C.* Enantioselective Construction of Six- and Seven-Membered Triorgano-Substituted Silicon-Stereogenic Heterocycles, Nat. Commun. 2021, 12, 1249.
(17) Yang, B.; Yang, W.; Guo, Y.; You, L.; He, C.* Enantioselective Silylation of Aliphatic C?H Bonds for the Synthesis of Silicon-Stereogenic Dihydrobenzosiloles, Angew. Chem., Int. Ed. 2020, 59, 22217?22222.
(18) Mu, D.; Yuan, W.; Chen, S.; Wang, N.; Yang, B.; You, L.; Zu, B.; Yu, P.; He, C.* Streamlined Construction of Silicon-Stereogenic Silanes by Tandem Enantioselective C?H Silylation/Alkene Hydrosilylation, J. Am. Chem. Soc. 2020, 142, 13459?13468.
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2018年課題組成立以來,我們圍繞特色手性主族元素中心(硅、硼、鍺、硫等)的高效構建,以及相關雜原子手性分子功能和應用的探索,開展了一系列的研究工作。目前已經有了充分的積累和良好的進展。我們非常歡迎具有科研理想、創新能力、勤奮努力的同學和有志之士加入本課題組,共同奮斗和成長。我們誠摯邀請所有優秀的申請者在方便的時候到深圳實地訪問參觀我們學院和實驗室。
實驗室主頁:http://faculty.sustech.edu.cn/hec/,聯系方式:hec@sustech.edu.cn