師資
個人簡介:
本人于2021年獲得香港科技大學生物化學系博士學位后,跟隨導師張明杰院士加入南方科技大學。主要從事突觸內GTP酶調節蛋白和抑制性突觸后重要蛋白及蛋白復合體的結構和功能研究。
研究領域:
1. 抑制性突觸后致密帶中蛋白質復合體的動態組裝與相分離調控的分子機制研究;
2. 小G蛋白及其調節因子在突觸形成及可塑性調控中的作用機制研究。
工作經歷:
2021/08-2023/07 南方科技大學 生命科學學院 神經生物學系 博士后
2023/08-2024/09 南方科技大學 生命科學學院 神經生物學系 高級研究學者
學習經歷:
2016/09-2021/06 香港科技大學 生命科學 PH.D
2012/09-2016/06 中國科學技術大學 生物科學 學士
代表文章:
1. Guanhua Bai, Yu Wang, and Mingjie Zhang*, "Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation," Cell Res, vol. 31, pp. 312-325, Mar 2021.
2. Guanhua Bai#, Hao Li#, Pengwei Qin, Yiqing Guo, Wanfa Yang, Yinmiao Lian, Fei Ye, Jianxin Chen, Meiling Wu, Ruifeng Huang, Jinsong Li, Youming Lu, Mingjie Zhang*,"Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under physiological and pathological conditions," J Cell Biol, vol. 222, Dec 4 2023.
3. Guanhua Bai and Mingjie Zhang*, "Inhibitory postsynaptic density from the lens of phase separation," Oxford Open Neuroscience, vol. 1, 2022.
4. Guanhua Bai and Mingjie Zhang*, "Mesophasic Assembly of Inhibitory Postsynaptic Density," Neurosci Bull, vol. 37, pp. 141-143, Jan 2021.
5. Guanhua Bai and Mingjie Zhang*, "Clustering acetylcholine receptors in neuromuscular junction by phase-separated Rapsn condensates," Neuron, vol. 109, pp. 1907-1909, Jun 16 2021.
6. Menglong Zeng, Guanhua Bai, and Mingjie Zhang*, "Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation," Small GTPases, vol. 10, pp. 296-304, Jul 2019.