師資
個人簡介
傅暘，博士，南方科技大學醫學院生物化學系正高級研究員/長聘副教授，博士生導師，國家海外高層次青年人才，深圳市孔雀人才。現任南方科技大學生物安全平臺副主任、冷凍電鏡委員會委員。2013年獲南開大學生物化學與分子生物學博士學位、哈佛大學醫學院聯合培養微生物學博士。師從世界著名微生物學家、美國科學院院士John Mekalanos教授。
本團隊的科研工作方向可以總結為‘圍繞一個核心，開拓一條新線’。一個核心：即變形菌門細菌的大分子跨膜遞送系統相關蛋白和遺傳元件的功能機制解析與應用研究；一條新線是指作為醫學院早期少數的微生物領域PI，我們響應國家與學校號召開展的：新冠與猴痘病毒等新發突發傳染病病原的應急攻關科學研究。聚焦在細菌大分子跨膜遞送這個研究核心，我們以弧菌、假單胞菌、氣單胞菌等細菌的II型、III型和VI型分泌系統及其效應蛋白研究對象，面向：1）精準抗菌機制與機理；2）致病性與宿主防御；3）相關應用技術，展開了深入而系列化研究。同時，通過前期在‘病原蛋白與宿主互作’領域的理論與技術積累，我們在新發病毒研究的這條輔線中，面向抗體與藥物靶點研究，也已形成了自己的科研特色。目前傅暘團隊累計發表研究論文37篇（南科大29篇)，其中入職前在Cell Host & Microbe、PNAS等雜志發表論文多篇，入職后以通訊作者（含共同）身份發表論文14篇，包括Mol Cell, Gut Microbes, J Biol Chem(2篇), Microbiol Res (2篇)，mLife, Virology, Allergy等，全部以南科大為本人唯一署名單位。論文總引超5620次。
本團隊累計主持國家自然科學基金委面上項目和青年項目、深圳市科創委基礎研發重點專項、深圳市科創委孔雀團隊項目、深圳市抗疫應急攻關重點專項、深圳市醫學科學院（SMART）等十余項項目。
學術任職
1、Bio-Protocol雜志編輯
2、Frontiers Cellular and Infection Microbiology專刊編輯
獲獎榮譽
1、國家級人才頭銜
2、深圳市人才頭銜
3、Fogarty Global Health Fellowship
教育經歷
1、2001.09-2005.06 江南大學，生物工程學專業學士
2、2006.09-2013.06 南開大學，生物化學與分子生物學專業博士
3、2009.09-2013.05 哈佛大學，微生物學與免疫生物學專業聯培博士
工作經歷：
1、2005.07-2006.08 南開大學，技術員
2、2008.06-2009.01 哈佛大學公共衛生學院，交換生
3、2013.07-2018.06 哈佛大學醫學院，博士后研究員
4、2018.07-2019.06 哈佛大學醫學院，助理研究員
5、2019.06-2020.12 南方科技大學，助理教授/博士生導師
6、2021.01-至今 南方科技大學，副教授/博士生導師
代表性論文：
* Contributed equally to the work and # for corresponding authors
Representative papers at SUSTech as a Corresponding author:
(1) Liu M, Wang H, Wang Z, Wang H, Zhang K, Xue J, Liu RH, Liu Y, Xia PY, Wang H, Kan B, Li Y, Li S, Fu Y#. A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics, a precision antimicrobial mechanism. Cell Host and Microbe. 2025, in press.
(2) Wang H, Liu Y, Wang Z, Xia P, Li Z, Liu M#, Fu Y#. Functional Insights into the Type VI Secretion System of Multi-drug Resistant Aeromonas hydrophila: A Key Factor in Competition and Pathogenesis. mLife. 2025, in press. DOI: 10.1002/mlf2.70018.
(3) Guo HH, Zhang Q, Wang Z, Zhang K#, Fu Y#. Structural insight into Vibrio cholerae EIIC Sugar Transporter Dimer Captured in a Substrate-Free Inward-facing State. Acta Biochimica et Biophysica Sinica. 2025, in press.
(4) Feng Q*, Dai, X, Wu, Q, Zhang L#, Yang L#, Fu Y#. C-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa. mSphere. 2025; e01026-24.
(5) Yu B*, Lu Q*, Li J*, Cheng X*, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y#, Fu Y#, Zhang J#. Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J Biol Chem. 2024;300(6):107288.
(6) Xiang Q*, Wu J, Zhou Y, Li L, Tian M, Li G#, Zhang Z#, Fu Y#. SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin. Microbiol Res. 2024; 282:127659.
(7) Feng Q*, Zhou J, Zhang L, Fu Y#, Yang L#. Insights into the molecular basis of c-diGMP signalling in Pseudomonas aeruginosa. Crit Rev Microbiol. 2024;50(1):20-38.
(8) Zhang Y*, Wang D*, Xiang Q*, Hu X, Zhang Y, Wu L, Zhang Z, Wang Y, Zhao J, McCormick PJ, Fu J#, Fu Y#, Zhang J#, Jiang H#, Li J#. A potent neutralizing nanobodytargeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein. Virology. 2024; 589:109925.
(9) Liu M*, Wang H*, Liu Y, Tian M, Wang Z, Shu RD, Zhao MY, Chen WD, Wang H, Wang H, Fu Y#. The phospholipase effector Tle1(Vc) promotes Vibrio cholerae virulence by killing competitors and impacting gene expression. Gut Microbes. 2023; 15(1): 2241204.
(10) Liu M*, Zhao MY*, Wang H, Wang ZH, Wang Z, Liu Y, Li YP, Dong T, Fu Y#. Pesticin-Like Effector VgrG3(cp) Targeting Peptidoglycan Delivered by the Type VI Secretion System Contributes to Vibrio cholerae Interbacterial Competition. Microbiol Spectr. 2023; 11(1): e0426722.
(11) Zhang K*, Peng T*, Tao X*, Tian M*, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y#, Li S#. Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol Cell. 2022;82(24):4712-4726 e4717.
(12) Xiang Q, Li L, Wu J, Tian M, Fu Y#. Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies. Microbiol Res. 2022; 258:126993. [JCR: Q1].
(13) Song X*, Li J*, Tian M*, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y#, Duan J#, Zhang J#. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem. 2022;298(2):10148.
(14) Chen Y*, Wang S*, Huang J*, Fu Y, Wen J, Zhou C, Fu Y#, Liu L#. Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19. Clin Hemorheol Microcirc. 2021; 78(2):199-207. [JCR: Q3].
(15) Cai Q*, Huang D*, Ou P*, Yu H, Zhu Z, Xia Z, Su Y, Ma Z, Zhang Y, Li Z, He Q, Liu L#, Fu Y#, Chen J#. COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020;75(7):1742-1752. [JCR: Q1].
Before joining SUSTech
(16) Fu Y*, Ho BT*, Mekalanos JJ#. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host and Microbe. 2018; 23(2): 274-281 e272.
(17) Ho BT*, Fu Y*, Dong TG, Mekalanos JJ#. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci USA. 2017;114(35):9427-9432.
(18) Fu Y, Waldor MK, Mekalanos JJ#. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host and Microbe. 2013; 14(6): 652-663.