師資
個人簡介：
牛鋒鋒博士，現為南方科技大學生命科學學院研究副教授，碩士生導師。本科畢業于南開大學，隨后在中科院生物物理研究所獲得生物化學與分子生物學專業博士學位。2016年加入南方科技大學，歷任博士后，研究助理教授和研究副教授。主要利用生物化學、結構生物學及細胞生物學等手段，研究人體和病原體內生物大分子的結構與功能。近年來主要從事分子馬達蛋白介導的胞內物質運輸的分子機制研究。
研究領域：
結構生物學；細胞內物質運輸。
工作經歷：
2023 - 至今，南方科技大學，生命科學學院，研究副教授；
2019 - 2023，南方科技大學，生命科學學院/前沿與交叉科學研究院，研究助理教授；
2016 - 2019，南方科技大學，生物系，博士后。
學習經歷：
2009 - 2015，中國科學院生物物理研究所，生物化學與分子生物學，博士；
2005 - 2009，南開大學，生命科學，學士。
代表文章：
1. Niu, F.*, Li, L.*, Wang, L., Xiao, J, Xu, S., Liu, Y., Lin, L., Yu, C.#, Wei, Z.#. Autoinhibition and activation of myosin VI revealed by its cryo-EM structure. Nat. Comm. 2024 Jan. (accepted)
2. Jia, X.*; Lin, L.*; Xu, S.; Li, L.; Wei, Z.; Yu, C.#; Niu, F.# Crystal Structure of the SH3 Domain of ASAP1 in Complex with the Proline Rich Motif (PRM) of MICAL1 Reveals a Unique SH3/PRM Interaction Mode. Int. J. Mol. Sci. 2023, 24, 1414. https://doi.org/10.3390/ijms24021414
3. Niu, F.*#, Liu, Y.*, Sun, K.*, Xu, S., Dong, J., Yu, C., Yan, K., Wei, Z#. Autoinhibition and Activation Mechanisms Revealed by the Triangular-shaped Structure of Myosin Va. Sci Adv. 2022 Dec 9;8(49):eadd4187. doi: 10.1126/sciadv.add4187. Epub 2022 Dec 9. PMID: 36490350.
4. Liu Y, Li L, Yu C, Zeng F, Niu F#, Wei Z#. Cargo Recognition Mechanisms of Yeast Myo2 Revealed by AlphaFold2-Powered Protein Complex Prediction. Biomolecules. 2022 Jul 26;12(8):1032. doi: 10.3390/biom12081032. PMID: 35892342; PMCID: PMC9330073.
5. Liang, M.*, Jin, G.*, Xie, X.*, Zhang, W., Li, K., Niu, F., Yu, C., Wei, Z. Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep. 2021 Mar 23;34(12):108901. doi: 10.1016/j.celrep.2021.108901. PMID: 33761347.
6. Niu, F.*, Sun, K.*, Wei, W., Yu, C., Wei, Z. F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Sci Adv. 2020 Nov 6;6(45):eabb1307. doi: 10.1126/sciadv.abb1307. PMID: 33158857; PMCID: PMC7673715.
7. Li, J. *, Rodriguez, J. P. *, Niu, F., Pu, M., Wang, J., Hung, L. W., … & Ouyang, S. (2016). Structural basis for DNA recognition by STAT6. Proceedings of the National Academy of Sciences, 113(46), 13015-13020.
8. Burakova, L. P., Natashin, P. V., Malikova, N. P., Niu, F., Pu, M., Vysotski, E. S., & Liu, Z. J. (2016). All Ca 2+-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg2+-loaded apo-berovin. Journal of Photochemistry and Photobiology B: Biology, 154, 57-66.
9. Jiao, L.*, Ouyang, S.*, Shaw, N., Song, G., Feng, Y., Niu, F., … & Liu, Z. J. (2014). Mechanism of the Rpn13-induced activation of Uch37. Protein & Cell, 1-15.
10. Gu, J., Feng, Y., Feng, X., Sun, C., Lei, L., Ding, W., Niu, F., … & Han, W. (2014). Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin. PLoS pathogens, 10(5), e1004109.
11. Niu, F.*, Shaw, N*., Wang, Y. E.*, Jiao, L.*, Ding, W., Li, X., … & Liu, Z. J. (2013). Structure of the Leanyer orthobunyavirus nucleoprotein–RNA complex reveals unique architecture for RNA encapsidation. Proceedings of the National Academy of Sciences, 110(22), 9054-9059.
12. Jiao, L.*, Ouyang, S.*, Liang, M.*, Niu, F.*, Shaw, N., Wu, W., … & Liu, Z. J. (2013). Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential. Journal of virology, 87(12), 6829-6839.
13. Niu, F., Ru, H., Ding, W., Ouyang, S., & Liu, Z. J. (2013). Structural biology study of human TNF receptor associated factor 4 TRAF domain. Protein & cell, 4(9), 687-694.
14. Ouyang, S.*, Song, X.*, Wang, Y.*, Ru, H.*, Shaw, N., Jiang, Y., Niu, F., … & Liu, Z. J. (2012). Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity, 36(6), 1073-1086.
(*co-first author, #corresponding author)