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Professor Zhang Wenyong is a molecular pathologist. He obtained a full scholarship to study at Bowdoin College in 1992 and graduated with the hightest distinction with a major in biochemistry. He was then admitted to the distinguished "Tri-institutional MD-PhD Program" at Cornell Medical School/Rockefeller University and Sloan Kettering Caner Institute. He graduated in 2004 with The Herman L. Jacobius Pathology Award.  During the PhD work, he studied in the lab of the world leading expert in HIV biology, Dr. David Ho, and pionnerred in developing a potent HIV DNA vaccine by targeting dendritic cells. He received Elizabeth Glaser Pediatric AIDS Foundation Student Award for his work. He obtained residency training in anatomic pathology from Cornell Medical School- New York Presbyterian Hospital, and continued with a fellowhip in molecular pathology at Baylor College of Medicine/MD Anderson Cancer Center in Houston. He was then appointed Associated Director of molecular pathology laboratory at Mt. Sinai School of Medicine in 2008 and Director of Molecular Pathology Laboratory at New York Medical Collage Hospital in 2010. He has developed a number of highly accurate and effient methods for detecting molecular changes associated with cancer.

Research

Professional Experience

2017.5 - Professor, Southern University Of Science and Techonlogy School Of Medicine

2016.6 - Chief Medical Officer, Cheerland Precision Biomed

2010.7-2016.5 Chief pathologist, Director of Molecular pathology laboratory, New York Medical College affiliated hospital

2008.7-2010.6 Assistant chief pathologist, Assistant lab director of Molecular pathology laboratory , Mount Sinai School Of Medicine

2007.7-2008.7 Fellowship doctor, Baylor College Of Medicine and MD Anderson Cancer Center

2004.8-2007.6 Resident doctor, New York University School Of Medicine, in histopathology

Education

1992.9-1996.5 Bachelor degree in biochemistry, Bowdoin College

1996.8-2004.5 MD-PhD, joint training in Cornell University School of Medicine, Rockefeller University, and Sloan-Kettering Cancer Institute

HONORS AND AWARDS

2004 The Herman L. Jacobius Prize

2000 Elizabeth Glaser Pediatric AIDS Foundation Student Award

1996-2004 MD-PHD training funds of NIH

1996 Summa Cum Laude, Bowdoin College

1996 Phi Beta Kappa, Bowdoin College

1992-1996 Full scholarship, Bowdoin College

Certificate

Medical license in New York state (since 2004)

American Anatomic Pathology Specialty Certificate (since 2008)

Authored Books

J. Zhuge, W. Zhang. Principles of molecular biology in Molecular Diagnosis of Skin Diseases (M. Murphy, ed). Humana Press (2011).

Journal Papers

He pioneered in developing a potent HIV DNA vaccine by targeting dendritic cells. He received Elizabeth Glaser Pediatric AIDS Foundation Student Award for his work. He has developed simple, efficient and accurate detection methods for multiple cancer target genes, including BRAFV600E, MPLW515L/K, EWSR1/ATF1, EWSR1/CREB1, JAK2V617F, etc.

1. Meng T., Lan Z., Zhao X., Niu L., Chen C., & Zhang W. Comprehensive bioinformatics analysis of functional molecules in colorectal cancer. Journal Of Gastrointestinal Oncology 2022, 13(1), 231-245.

2. Luan H, Gu W, Li H, Wang Z, Lu L, Ke M, Lu J, Chen W, Lan Z, Xiao Y, Xu J, Zhang Y, Cai Z, Liu S, Zhang W. Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients. J Transl Med. 2021 Dec 7;19(1):500.

3. Qin J, Shi X, Xu J, Yuan S, Zheng B, Zhang E, Huang G, Li G, Jiang G, Gao S, Tian C, Guo R, Fu Z, Huang Q, Yang R, Zhang W, Li S, Wu S. Characterization of the Genitourinary Microbiome of 1,165 Middle-Aged and Elderly Healthy Individuals. Front Microbiol. 2021 Aug 19;12:673969.

4. Zhao X, Li Z, Wang L, Lan Z, Lin F, Zhang W, Su Z. A Chinese family with Noonan syndrome caused by a heterozygous variant in LZTR1: a case report and literature review. BMC Endocr Disord. 2021 Jan 6;21(1):2.

5. Ying Liu, Zhangzhang Lan , Fang Zhao, Shuangchuan Zhang, Wenyong Zhang. Analysis of a Chinese pedigree with familial chylomicronemia syndrome reveals two novel LPL mutations by whole-exome sequencing. Frontiers in Genetics 2020 Jul 17;11:741.

6. Min Li; Haitao Jia; Qiuqin Qian; Peng Wen; Chuan Chen; Yaqiong Hua; Kai Wang; Wenyong Zhang; Feng Shi. Genomic Characterization of High-Recurrence Risk Papillary Thyroid Carcinoma in Southern Chinese populations. Diagnostic Pathology 2020 15:49.

7. Luan H, Jiang X, Ji F, Lan Z, Cai Z, Zhang W. CPVA: a web-based metabolomic tool for chromatographic peak visualization and annotation. Bioinformatics. 2020 Mar 18. pii: btaa200.

8. Ou J, Yang C, Cui X, Chen C, Ye S, Zhang C, Wang K, Chen J, Zhang Q, Qian C, Fang G, Zhang W. Successful pregnancy after prenatal diagnosis by NGS for a carrier of complex chromosome rearrangements. Reprod Biol Endocrinol. 2020 Feb 29;18(1):15.

9. Geng Q, Cui X, Zhang Y, Zhang L, Zhang C, Wang K, Chen J, Zhu Q, Xie J, Xu Z, Liu Y, Zhang M, Ding L, Zhang W, Yang C. Screening of Triploid with Low-coverage Whole-genome Sequencing by A Single-nucleotide Polymorphism-based Test in Miscarriage Tissue  J Assist Reprod Genet. 2019 Dec;36(12):2525-2531.

10. Luo A, Cheng D, Yuan S, Li H, Du J, Zhang Y, Yang C, Lin G, Zhang W, Tan YQ. Maternal interchromosomal insertional translocation leading to 1q43-q44 deletion and duplication in two siblings. Mol Cytogenet. 2018 Apr 4;11:24 (共同通訊作者).

11. T. Huang, J. Zhuge, W. Zhang. Sensitive detection of BRAF V600E mutation by Amplification Refractory Mutation System (ARMS)-PCR. Biomarker Research 2013; 1:3.

12. Li Z, Cai X, Cai CL, Wang J, Zhang W, Petersen BE, Yang FC, Xu M. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011 Oct 27;118(17):4509-18.

13. L. Varricchio, E. Masselli, E. Alfani, W. Zhang, R. Hoffman, AR Migliaccio. The dominant negative b isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells. Blood 2011, 118(2): 425-36.

14. J. Zhuge, W. Zhang. Sensitive detection of MPLW515L/K mutations by amplification refractory mutation system (ARMS)-PCR. Clinica Chimica Acta 2010; 411:122-123.

15. W. Zhang, D. Jones. Predictors of primary imatinib resistance in chronic myeloid leukemia are distinct from those in secondary resistance. J Clin Oncology. 2009; 27: 3642-3649.

16. W. Zhang, D. López-Terrada. Molecular monitoring of 8p11 myeloproliferative syndrome in an infant. J Pediatr Hematol Oncol 2009;31:879-883.

17. Wenyong W. Zhang, Jorge E. Cortes, Hui Yao, Li Zhang, Neelima G. Reddy, Elias Jabbour, Hagop M. Kantarjian, and Dan Jones. Predictors of Primary Imatinib Resistance in Chronic Myelogenous Leukemia Are Distinct From Those in Secondary Imatinib Resistance.J Clin Oncology. 2009 Aug 1;27(22):3642-9

18. W. Wang, E. Mayordomo, W. Zhang, V. S. Hernandez, D. Tuvin, L. Garcia, D. C. Lev, A. J. F. Lazar, D. López-Terrada. Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in Clear Cell Sarcoma (Melanoma of Soft Parts). Modern Pathology 2009; 22:1201-1209.

19. Z. Chen, W. Zhang, D. Ho. Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'. JAIDS 2008; 47: 412-421.

20. Y. Huang, Z. Chen, W. Zhang, D. Gurner, Y. Song, D. Gardiner, D. D. Ho. Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant. JAIDS 2008; 47: 403-411.

21. Y. Huang, A. Chen, X. Li, Z. Chen, W. Zhang, Y. Song, D. Gurner, D. Gardiner, S. Basu, D. D. Ho and M. Tsuji. Enhancement of HIV DNA vaccine immunogenicity by the NK T cell ligand, -galactosylceramide. Vaccine 2008; 26:1807-1816.

22. W. Zhang, J. Versalovic. Expanding the diagnostic capabilities of molecular microbiology by genomic methods. Journal of Molecular Diagnostics 2007; 9(5): 572-573.

23. W. Zhang, J. E. Dahlberg, W. Tam. MicroRNAs in tumorigenesis: a primer for pathologists. American Journal of Pathology 2007; 171(3):728-738.

24. W. Zhang, H. Syed. Mammary small cell carcinoma with dimorphic phenotype. Breast Journal 2007; 13(5): 529-530.

25. L. Zhang, W. Yu, T. He, J. Yu, R. E. Caffrey, E. A. Dalmasso, S. Fu, T. Pham, J. Mei, J. J. Ho, W. Zhang, P. Lopez, D. D. Ho. Contribution of human {alpha}-Defensin-1, -2 and -3 to the anti-HIV-1 activity of CD8 antiviral factor. Science 2002; 298:995-1000.

26. B. Stibrková, J. Majewski, I. Sebesta, W. Zhang, J. Ott, S. Kmoch. Familial juvenile hyperuricemic nephropathy: localization of the gene on chromosome 16p11.2-and evidence for genetic heterogeneity. Am. J. Human Genetics 2000; 66:1989-1994